Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning

Matthew T. C. Brown, Kelly R. Tan, Eoin C. O’Connor, Irina Nikonenko, Dominique Muller and Christian Lüscher ()
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Matthew T. C. Brown: Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland
Kelly R. Tan: Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland
Eoin C. O’Connor: Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland
Irina Nikonenko: Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland
Dominique Muller: Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland
Christian Lüscher: Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland

Nature, 2012, vol. 492, issue 7429, 452-456

Abstract: GABA-releasing neurons from the ventral tegmental area that project to the nucleus accumbens are shown to block the firing of cholinergic accumbal interneurons, affecting learning in mice.

Date: 2012
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DOI: 10.1038/nature11657

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