Seventy-five genetic loci influencing the human red blood cell

Pim van der Harst (), Weihua Zhang, Irene Mateo Leach, Augusto Rendon, Niek Verweij, Joban Sehmi, Dirk S. Paul, Ulrich Elling, Hooman Allayee, Xinzhong Li, Aparna Radhakrishnan, Sian-Tsung Tan, Katrin Voss, Christian X. Weichenberger, Cornelis A. Albers, Abtehale Al-Hussani, Folkert W. Asselbergs, Marina Ciullo, Fabrice Danjou, Christian Dina, Tõnu Esko, David M. Evans, Lude Franke, Martin Gögele, Jaana Hartiala, Micha Hersch, Hilma Holm, Jouke-Jan Hottenga, Stavroula Kanoni, Marcus E. Kleber, Vasiliki Lagou, Claudia Langenberg, Lorna M. Lopez, Leo-Pekka Lyytikäinen, Olle Melander, Federico Murgia, Ilja M. Nolte, Paul F. O’Reilly, Sandosh Padmanabhan, Afshin Parsa, Nicola Pirastu, Eleonora Porcu, Laura Portas, Inga Prokopenko, Janina S. Ried, So-Youn Shin, Clara S. Tang, Alexander Teumer, Michela Traglia, Sheila Ulivi, Harm-Jan Westra, Jian Yang, Jing Hua Zhao, Franco Anni, Abdel Abdellaoui, Antony Attwood, Beverley Balkau, Stefania Bandinelli, François Bastardot, Beben Benyamin, Bernhard O. Boehm, William O. Cookson, Debashish Das, Paul I. W. de Bakker, Rudolf A. de Boer, Eco J. C. de Geus, Marleen H. de Moor, Maria Dimitriou, Francisco S. Domingues, Angela Döring, Gunnar Engström, Gudmundur Ingi Eyjolfsson, Luigi Ferrucci, Krista Fischer, Renzo Galanello, Stephen F. Garner, Bernd Genser, Quince D. Gibson, Giorgia Girotto, Daniel Fannar Gudbjartsson, Sarah E. Harris, Anna-Liisa Hartikainen, Claire E. Hastie, Bo Hedblad, Thomas Illig, Jennifer Jolley, Mika Kähönen, Ido P. Kema, John P. Kemp, Liming Liang, Heather Lloyd-Jones, Ruth J. F. Loos, Stuart Meacham, Sarah E. Medland, Christa Meisinger, Yasin Memari, Evelin Mihailov, Kathy Miller, Miriam F. Moffatt, Matthias Nauck, Maria Novatchkova, Teresa Nutile, Isleifur Olafsson, Pall T. Onundarson, Debora Parracciani, Brenda W. Penninx, Lucia Perseu, Antonio Piga, Giorgio Pistis, Anneli Pouta, Ursula Puc, Olli Raitakari, Susan M. Ring, Antonietta Robino, Daniela Ruggiero, Aimo Ruokonen, Aude Saint-Pierre, Cinzia Sala, Andres Salumets, Jennifer Sambrook, Hein Schepers, Carsten Oliver Schmidt, Herman H. W. Silljé, Rob Sladek, Johannes H. Smit, John M. Starr, Jonathan Stephens, Patrick Sulem, Toshiko Tanaka, Unnur Thorsteinsdottir, Vinicius Tragante, Wiek H. van Gilst, L. Joost van Pelt, Dirk J. van Veldhuisen, Uwe Völker, John B. Whitfield, Gonneke Willemsen, Bernhard R. Winkelmann, Gerald Wirnsberger, Ale Algra, Francesco Cucca, Adamo Pio d’Adamo, John Danesh, Ian J. Deary, Anna F. Dominiczak, Paul Elliott, Paolo Fortina, Philippe Froguel, Paolo Gasparini, Andreas Greinacher, Stanley L. Hazen, Marjo-Riitta Jarvelin, Kay Tee Khaw, Terho Lehtimäki, Winfried Maerz, Nicholas G. Martin, Andres Metspalu, Braxton D. Mitchell, Grant W. Montgomery, Carmel Moore, Gerjan Navis, Mario Pirastu, Peter P. Pramstaller, Ramiro Ramirez-Solis, Eric Schadt, James Scott, Alan R. Shuldiner, George Davey Smith, J. Gustav Smith, Harold Snieder, Rossella Sorice, Tim D. Spector, Kari Stefansson, Michael Stumvoll, W. H. Wilson Tang, Daniela Toniolo, Anke Tönjes, Peter M. Visscher, Peter Vollenweider, Nicholas J. Wareham, Bruce H. R. Wolffenbuttel, Dorret I. Boomsma, Jacques S. Beckmann, George V. Dedoussis, Panos Deloukas, Manuel A. Ferreira, Serena Sanna, Manuela Uda, Andrew A. Hicks, Josef Martin Penninger, Christian Gieger (), Jaspal S. Kooner (), Willem H. Ouwehand (), Nicole Soranzo () and John C. Chambers ()
Additional contact information
Pim van der Harst: University of Groningen, University Medical Center Groningen
Weihua Zhang: Imperial College London
Irene Mateo Leach: University of Groningen, University Medical Center Groningen
Augusto Rendon: University of Cambridge
Niek Verweij: University of Groningen, University Medical Center Groningen
Joban Sehmi: Ealing Hospital NHS Trust
Dirk S. Paul: Wellcome Trust Sanger Institute, Hinxton
Ulrich Elling: Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Hooman Allayee: University of Southern California Keck School of Medicine
Xinzhong Li: Institute of Clinical Sciences, Imperial College London
Aparna Radhakrishnan: University of Cambridge
Sian-Tsung Tan: Ealing Hospital NHS Trust
Katrin Voss: University of Cambridge
Christian X. Weichenberger: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
Cornelis A. Albers: University of Cambridge
Abtehale Al-Hussani: Imperial College London
Folkert W. Asselbergs: University Medical Center Utrecht
Marina Ciullo: Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR
Fabrice Danjou: Clinica Pediatrica 2a, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy.
Christian Dina: Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, BP 70721 44007 Nantes cedex, 1 Nantes, France.
Tõnu Esko: Estonian Genome Center of University of Tartu
David M. Evans: MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol
Lude Franke: University of Groningen, University Medical Center Groningen
Martin Gögele: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
Jaana Hartiala: University of Southern California Keck School of Medicine
Micha Hersch: University of Lausanne
Hilma Holm: deCODE genetics
Jouke-Jan Hottenga: VU University
Stavroula Kanoni: Wellcome Trust Sanger Institute, Hinxton
Marcus E. Kleber: Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg
Vasiliki Lagou: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
Claudia Langenberg: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital
Lorna M. Lopez: The University of Edinburgh
Leo-Pekka Lyytikäinen: Fimlab Laboratories, Tampere University Hospital
Olle Melander: Lund University
Federico Murgia: Institute of Population Genetics, National Research Council of Italy
Ilja M. Nolte: University of Groningen, University Medical Center Groningen
Paul F. O’Reilly: Imperial College London
Sandosh Padmanabhan: Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
Afshin Parsa: University of Maryland School of Medicine
Nicola Pirastu: Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy.
Eleonora Porcu: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy.
Laura Portas: Institute of Population Genetics, National Research Council of Italy
Inga Prokopenko: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
Janina S. Ried: Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
So-Youn Shin: Wellcome Trust Sanger Institute, Hinxton
Clara S. Tang: Queensland Institute of Medical Research
Alexander Teumer: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Michela Traglia: San Raffaele Scientific Institute
Sheila Ulivi: Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”- Trieste
Harm-Jan Westra: University of Groningen, University Medical Center Groningen
Jian Yang: University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital
Jing Hua Zhao: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital
Franco Anni: Clinica Pediatrica 2a, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy.
Abdel Abdellaoui: VU University
Antony Attwood: University of Cambridge
Beverley Balkau: Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Villejuif F-94807, France.
Stefania Bandinelli: Geriatric Unit, Azienda Sanitaria Firenze
François Bastardot: Centre Hospitalier Universitaire Vaudois
Beben Benyamin: Queensland Institute of Medical Research
Bernhard O. Boehm: University Hospital
William O. Cookson: National Heart and Lung Institute, Imperial College London
Debashish Das: The Hatter Cardiovascular Institute, University College London
Paul I. W. de Bakker: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht
Rudolf A. de Boer: University of Groningen, University Medical Center Groningen
Eco J. C. de Geus: VU University
Marleen H. de Moor: VU University
Maria Dimitriou: Nutrition and Dietetics, Harokopio University
Francisco S. Domingues: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
Angela Döring: Institute of Epidemiology I and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
Gunnar Engström: Lund University
Gudmundur Ingi Eyjolfsson: The Laboratory in Mjodd
Luigi Ferrucci: Clinical Research Branch, National Institute on Aging
Krista Fischer: Estonian Genome Center of University of Tartu
Renzo Galanello: Clinica Pediatrica 2a, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy.
Stephen F. Garner: University of Cambridge
Bernd Genser: Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg
Quince D. Gibson: University of Maryland School of Medicine
Giorgia Girotto: Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy.
Daniel Fannar Gudbjartsson: deCODE genetics
Sarah E. Harris: Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh
Anna-Liisa Hartikainen: Institute of Clinical Sciences, Obstetrics and Gynecology, University of Oulu
Claire E. Hastie: Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
Bo Hedblad: Lund University
Thomas Illig: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Jennifer Jolley: University of Cambridge
Mika Kähönen: Tampere University Hospital
Ido P. Kema: University of Groningen, University Medical Center Groningen
John P. Kemp: MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol
Liming Liang: Harvard School of Public Health, Cambridge, Massachusetts 02115, USA.
Heather Lloyd-Jones: University of Cambridge
Ruth J. F. Loos: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital
Stuart Meacham: University of Cambridge
Sarah E. Medland: Queensland Institute of Medical Research
Christa Meisinger: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
Yasin Memari: Wellcome Trust Sanger Institute, Hinxton
Evelin Mihailov: Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR
Kathy Miller: Ealing Hospital NHS Trust
Miriam F. Moffatt: National Heart and Lung Institute, Imperial College London
Matthias Nauck: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
Maria Novatchkova: Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Teresa Nutile: Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR
Isleifur Olafsson: Landspitali University Hospital
Pall T. Onundarson: Faculty of Medicine, University of Iceland
Debora Parracciani: Genetic Park of Ogliastra, Perdasdefogu
Brenda W. Penninx: VU University Medical Centre
Lucia Perseu: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy.
Antonio Piga: University of Torino
Giorgio Pistis: San Raffaele Scientific Institute
Anneli Pouta: Institute of Health Sciences, University of Oulu
Ursula Puc: Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Olli Raitakari: Turku University Hospital
Susan M. Ring: The School of Social and Community Medicine, University of Bristol
Antonietta Robino: Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy.
Daniela Ruggiero: Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR
Aimo Ruokonen: Institute of Diagnostics, University of Oulu
Aude Saint-Pierre: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
Cinzia Sala: San Raffaele Scientific Institute
Andres Salumets: Competence Centre on Reproductive Medicine and Biology
Jennifer Sambrook: University of Cambridge
Hein Schepers: University of Groningen, University Medical Center Groningen
Carsten Oliver Schmidt: Institute for Community Medicine, University Medicine Greifswald
Herman H. W. Silljé: University of Groningen, University Medical Center Groningen
Rob Sladek: Faculty of Medicine, McGill University
Johannes H. Smit: VU University Medical Centre
John M. Starr: Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh
Jonathan Stephens: University of Cambridge
Patrick Sulem: deCODE genetics
Toshiko Tanaka: Clinical Research Branch, National Institute on Aging
Unnur Thorsteinsdottir: deCODE genetics
Vinicius Tragante: University Medical Center Utrecht
Wiek H. van Gilst: University of Groningen, University Medical Center Groningen
L. Joost van Pelt: University of Groningen, University Medical Center Groningen
Dirk J. van Veldhuisen: University of Groningen, University Medical Center Groningen
Uwe Völker: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
John B. Whitfield: Queensland Institute of Medical Research
Gonneke Willemsen: VU University
Bernhard R. Winkelmann: ClinPhenomics Study Center
Gerald Wirnsberger: Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Ale Algra: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht
Francesco Cucca: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy.
Adamo Pio d’Adamo: Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy.
John Danesh: University of Cambridge
Ian J. Deary: The University of Edinburgh
Anna F. Dominiczak: Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
Paul Elliott: Imperial College London
Paolo Fortina: Thomas Jefferson University Jefferson Medical College
Philippe Froguel: Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute
Paolo Gasparini: Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy.
Andreas Greinacher: Institute for Immunology and Transfusion Medicine, University Medicine Greifswald
Stanley L. Hazen: Center for Cardiovascular Diagnostics and Prevention, Lerner Research Institute, Cleveland Clinic
Marjo-Riitta Jarvelin: Imperial College London
Kay Tee Khaw: Clinical Gerontology Unit, Box 251, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Terho Lehtimäki: Fimlab Laboratories, Tampere University Hospital
Winfried Maerz: Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg
Nicholas G. Martin: Queensland Institute of Medical Research
Andres Metspalu: Estonian Genome Center of University of Tartu
Braxton D. Mitchell: University of Maryland School of Medicine
Grant W. Montgomery: Queensland Institute of Medical Research
Carmel Moore: University of Cambridge
Gerjan Navis: University of Groningen, University Medical Center Groningen
Mario Pirastu: Institute of Population Genetics, National Research Council of Italy
Peter P. Pramstaller: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
Ramiro Ramirez-Solis: Wellcome Trust Sanger Institute, Hinxton
Eric Schadt: Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine
James Scott: National Heart and Lung Institute, Imperial College London
Alan R. Shuldiner: University of Maryland School of Medicine
George Davey Smith: MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol
J. Gustav Smith: Lund University
Harold Snieder: University of Groningen, University Medical Center Groningen
Rossella Sorice: Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR
Tim D. Spector: Kings College London
Kari Stefansson: deCODE genetics
Michael Stumvoll: University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany.
W. H. Wilson Tang: Center for Cardiovascular Diagnostics and Prevention, Lerner Research Institute, Cleveland Clinic
Daniela Toniolo: San Raffaele Scientific Institute
Anke Tönjes: University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany.
Peter M. Visscher: Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh
Peter Vollenweider: Centre Hospitalier Universitaire Vaudois
Nicholas J. Wareham: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital
Bruce H. R. Wolffenbuttel: University of Groningen, University Medical Center Groningen
Dorret I. Boomsma: VU University
Jacques S. Beckmann: University of Lausanne
George V. Dedoussis: Nutrition and Dietetics, Harokopio University
Panos Deloukas: Wellcome Trust Sanger Institute, Hinxton
Manuel A. Ferreira: Queensland Institute of Medical Research
Serena Sanna: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy.
Manuela Uda: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy.
Andrew A. Hicks: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
Josef Martin Penninger: Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Christian Gieger: Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Jaspal S. Kooner: Ealing Hospital NHS Trust
Willem H. Ouwehand: University of Cambridge
Nicole Soranzo: Wellcome Trust Sanger Institute, Hinxton
John C. Chambers: Imperial College London

Nature, 2012, vol. 492, issue 7429, 369-375

Abstract: Abstract Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P

Date: 2012
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature11677 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:492:y:2012:i:7429:d:10.1038_nature11677

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature11677

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().