Tet1 controls meiosis by regulating meiotic gene expression

Shinpei Yamaguchi, Kwonho Hong, Rui Liu, Li Shen, Azusa Inoue, Dinh Diep, Kun Zhang () and Yi Zhang ()
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Shinpei Yamaguchi: Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Kwonho Hong: Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Rui Liu: University of California at San Diego
Li Shen: Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Azusa Inoue: Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Dinh Diep: University of California at San Diego
Kun Zhang: University of California at San Diego
Yi Zhang: Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA

Nature, 2012, vol. 492, issue 7429, 443-447

Abstract: A loss-of-function approach in mice is used to show that the methylcytosine dioxygenase Tet1 has a role in regulating meiosis and meiotic gene activation in female germ cells; Tet1 deficiency does not greatly affect genome-wide demethylation but has a more specific effect on the expression of a subset of meiotic genes.

Date: 2012
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DOI: 10.1038/nature11709

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