DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9

Patrice Y. Ohouo, Francisco M. Bastos de Oliveira, Yi Liu, Chu Jian Ma and Marcus B. Smolka ()
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Patrice Y. Ohouo: Weill Institute for Cell and Molecular Biology, Cornell University
Francisco M. Bastos de Oliveira: Weill Institute for Cell and Molecular Biology, Cornell University
Yi Liu: Weill Institute for Cell and Molecular Biology, Cornell University
Chu Jian Ma: Weill Institute for Cell and Molecular Biology, Cornell University
Marcus B. Smolka: Weill Institute for Cell and Molecular Biology, Cornell University

Nature, 2013, vol. 493, issue 7430, 120-124

Abstract: DNA damage or replication stress induces the activation of checkpoint kinases, pausing the cell cycle so that DNA repair can take place; checkpoint activation must be regulated to prevent the cell-cycle arrest from persisting after damage is repaired, and now the Slx4–Rtt107 complex is shown to regulate checkpoint kinase activity by directly monitoring DNA-damage signalling.

Date: 2013
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DOI: 10.1038/nature11658

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