Coordinated control of replication and transcription by a SAPK protects genomic integrity

Alba Duch, Irene Felipe-Abrio, Sonia Barroso, Gilad Yaakov, María García-Rubio, Andrés Aguilera, Eulàlia de Nadal and Francesc Posas ()
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Alba Duch: Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona E-08003, Spain
Irene Felipe-Abrio: Centro Andaluz de Biología Molecular and Medicina Regenerativa CABIMER, Universidad de Sevilla, 41092 Sevilla, Spain
Sonia Barroso: Centro Andaluz de Biología Molecular and Medicina Regenerativa CABIMER, Universidad de Sevilla, 41092 Sevilla, Spain
Gilad Yaakov: Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona E-08003, Spain
María García-Rubio: Centro Andaluz de Biología Molecular and Medicina Regenerativa CABIMER, Universidad de Sevilla, 41092 Sevilla, Spain
Andrés Aguilera: Centro Andaluz de Biología Molecular and Medicina Regenerativa CABIMER, Universidad de Sevilla, 41092 Sevilla, Spain
Eulàlia de Nadal: Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona E-08003, Spain
Francesc Posas: Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona E-08003, Spain

Nature, 2013, vol. 493, issue 7430, 116-119

Abstract: Upregulation of gene transcription in stressed cells can lead to clashes between the transcription and repair machineries; here, a stress-activated protein kinase (SAPK), Hog1, is shown to coordinate these two processes in yeast.

Date: 2013
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DOI: 10.1038/nature11675

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