Restriction of intestinal stem cell expansion and the regenerative response by YAP

Evan R. Barry, Teppei Morikawa, Brian L. Butler, Kriti Shrestha, Rosemarie de la Rosa, Kelley S. Yan, Charles S. Fuchs, Scott T. Magness, Ron Smits, Shuji Ogino, Calvin J. Kuo and Fernando D. Camargo ()
Additional contact information
Evan R. Barry: Children’s Hospital
Teppei Morikawa: Dana-Farber Cancer Institute and Harvard Medical School
Brian L. Butler: Children’s Hospital
Kriti Shrestha: Children’s Hospital
Rosemarie de la Rosa: Children’s Hospital
Kelley S. Yan: Stanford University
Charles S. Fuchs: Dana-Farber Cancer Institute and Harvard Medical School
Scott T. Magness: The University of North Carolina at Chapel Hill
Ron Smits: Erasmus MC, 3000 CA Rotterdam, The Netherlands
Shuji Ogino: Dana-Farber Cancer Institute and Harvard Medical School
Calvin J. Kuo: Stanford University
Fernando D. Camargo: Children’s Hospital

Nature, 2013, vol. 493, issue 7430, 106-110

Abstract: YAP has previously been identified as an oncogene that promotes cell growth, but now it is shown to restrict stem cell expansion during regeneration in the mouse intestine, suggesting that it may function as a tumour suppressor in colon cancer.

Date: 2013
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DOI: 10.1038/nature11693

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