Scaling of embryonic patterning based on phase-gradient encoding

Volker M. Lauschke, Charisios D. Tsiairis, Paul François and Alexander Aulehla ()
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Volker M. Lauschke: Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Charisios D. Tsiairis: Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Paul François: McGill University
Alexander Aulehla: Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany

Nature, 2013, vol. 493, issue 7430, 101-105

Abstract: An ex vivo primary culture assay is developed that recapitulates mouse embryonic mesodermal patterning and segment formation; using this approach, it is shown that oscillating gene activity is central to maintain stable proportions during development.

Date: 2013
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DOI: 10.1038/nature11804

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