COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis

Jun Qin, San-Pin Wu, Chad J. Creighton, Fangyan Dai, Xin Xie, Chiang-Min Cheng, Anna Frolov, Gustavo Ayala, Xia Lin, Xin-Hua Feng, Michael M. Ittmann, Shaw-Jenq Tsai, Ming-Jer Tsai () and Sophia Y. Tsai ()
Additional contact information
Jun Qin: Baylor College of Medicine
San-Pin Wu: Baylor College of Medicine
Chad J. Creighton: Dan L. Duncan Cancer Center, Baylor College of Medicine
Fangyan Dai: Baylor College of Medicine
Xin Xie: Baylor College of Medicine
Chiang-Min Cheng: Baylor College of Medicine
Anna Frolov: Baylor College of Medicine
Gustavo Ayala: Baylor College of Medicine
Xia Lin: Baylor College of Medicine
Xin-Hua Feng: Baylor College of Medicine
Michael M. Ittmann: Baylor College of Medicine
Shaw-Jenq Tsai: Baylor College of Medicine
Ming-Jer Tsai: Baylor College of Medicine
Sophia Y. Tsai: Baylor College of Medicine

Nature, 2013, vol. 493, issue 7431, 236-240

Abstract: A cell-autonomous role for the COUP-TFII transcription factor in prostate cancer cells is identified, in which COUP-TFII inhibits TGF-β signalling by binding to SMAD4; COUP-TFII promotes prostate tumorigenesis and metastasis in a mouse model, and is associated with more aggressive disease in human prostate cancers.

Date: 2013
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DOI: 10.1038/nature11674

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