Recombination-restarted replication makes inverted chromosome fusions at inverted repeats

Ken’Ichi Mizuno, Izumi Miyabe, Stephanie A. Schalbetter, Antony M. Carr () and Johanne M. Murray
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Ken’Ichi Mizuno: Genome Damage and Stability Centre, University of Sussex, Brighton, East Sussex BN1 9RQ, UK
Izumi Miyabe: Genome Damage and Stability Centre, University of Sussex, Brighton, East Sussex BN1 9RQ, UK
Stephanie A. Schalbetter: Genome Damage and Stability Centre, University of Sussex, Brighton, East Sussex BN1 9RQ, UK
Antony M. Carr: Genome Damage and Stability Centre, University of Sussex, Brighton, East Sussex BN1 9RQ, UK
Johanne M. Murray: Genome Damage and Stability Centre, University of Sussex, Brighton, East Sussex BN1 9RQ, UK

Nature, 2013, vol. 493, issue 7431, 246-249

Abstract: A new mechanism of chromosomal rearrangement is identified through the observation that broken or collapsed DNA replication forks restarted by homologous recombination have a high propensity for U-turns at short inverted repeats; the error-prone nature of this mechanism is suggested to contribute to gross chromosomal rearrangements and copy-number variations present in cancer and other genomic disorders.

Date: 2013
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DOI: 10.1038/nature11676

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