Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori

David Strugatsky, Reginald McNulty, Keith Munson, Chiung-Kuang Chen, S. Michael Soltis, George Sachs () and Hartmut Luecke ()
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David Strugatsky: David Geffen School of Medicine, University of California Los Angeles and Greater West Los Angeles Health Care System
Reginald McNulty: University of California
Keith Munson: David Geffen School of Medicine, University of California Los Angeles and Greater West Los Angeles Health Care System
Chiung-Kuang Chen: University of California
S. Michael Soltis: Stanford Synchrotron Radiation Lightsource, 2575 Sand Hill Road
George Sachs: David Geffen School of Medicine, University of California Los Angeles and Greater West Los Angeles Health Care System
Hartmut Luecke: University of California

Nature, 2013, vol. 493, issue 7431, 255-258

Abstract: The crystal structure of the inner-membrane urea channel HpUreI from Helicobacter pylori, the causative organism of peptic ulcers, reveals how the channel selectively transports urea across the membrane and buffers the pathogen’s periplasmic pH against the acidic gastric environment.

Date: 2013
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DOI: 10.1038/nature11684

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