Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation

Zhiqiang Yan, Wei Zhang, Ye He, David Gorczyca, Yang Xiang, Li E. Cheng, Shan Meltzer, Lily Yeh Jan and Yuh Nung Jan ()
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Zhiqiang Yan: Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
Wei Zhang: Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
Ye He: Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
David Gorczyca: Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
Yang Xiang: Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
Li E. Cheng: Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
Shan Meltzer: Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
Lily Yeh Jan: Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
Yuh Nung Jan: Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA

Nature, 2013, vol. 493, issue 7431, 221-225

Abstract: Mechanotransduction channels studied to date are mainly involved with sensing noxious mechanical stimuli; here NOMPC, a member of the TRP ion channel family, is identified as a pore-forming subunit of an ion channel essential to the sensation of gentle touch in Drosophila.

Date: 2013
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DOI: 10.1038/nature11685

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