Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Marlen Knobloch, Simon M. G. Braun, Luis Zurkirchen, Carolin von Schoultz, Nicola Zamboni, Marcos J. Araúzo-Bravo, Werner J. Kovacs, Özlem Karalay, Ueli Suter, Raquel A. C. Machado, Marta Roccio, Matthias P. Lutolf, Clay F. Semenkovich and Sebastian Jessberger ()
Additional contact information
Marlen Knobloch: Brain Research Institute, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland
Simon M. G. Braun: Brain Research Institute, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland
Luis Zurkirchen: Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland
Carolin von Schoultz: Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland
Nicola Zamboni: Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland
Marcos J. Araúzo-Bravo: Max Planck Institute for Molecular Biomedicine, 48149 Muenster, Germany
Werner J. Kovacs: Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland
Özlem Karalay: Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland
Ueli Suter: Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland
Raquel A. C. Machado: Brain Research Institute, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland
Marta Roccio: Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland
Matthias P. Lutolf: Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland
Clay F. Semenkovich: Washington University School of Medicine, Metabolism & Lipid Research, St. Louis, Missouri 63110, USA
Sebastian Jessberger: Brain Research Institute, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland

Nature, 2013, vol. 493, issue 7431, 226-230

Abstract: Adult neural stem and progenitor cells (NSPCs) show high levels of fatty acid synthase (Fasn)-dependent de novo lipogenesis, a process that is controlled by Spot14 to regulate the rate of proliferation; this indicates a functional coupling between the regulation of lipid metabolism and adult NSPC proliferation.

Date: 2013
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DOI: 10.1038/nature11689

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