How insulin engages its primary binding site on the insulin receptor

John G. Menting, Jonathan Whittaker, Mai B. Margetts, Linda J. Whittaker, Geoffrey K.-W. Kong, Brian J. Smith, Christopher J. Watson, Lenka Žáková, Emília Kletvíková, Jiří Jiráček, Shu Jin Chan, Donald F. Steiner, Guy G. Dodson, Andrzej M. Brzozowski, Michael A. Weiss (), Colin W. Ward and Michael C. Lawrence ()
Additional contact information
John G. Menting: Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
Jonathan Whittaker: School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
Mai B. Margetts: Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
Linda J. Whittaker: School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
Geoffrey K.-W. Kong: Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
Brian J. Smith: Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
Christopher J. Watson: York Structural Biology Laboratory, University of York
Lenka Žáková: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 16610 Prague, Czech Republic
Emília Kletvíková: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 16610 Prague, Czech Republic
Jiří Jiráček: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 16610 Prague, Czech Republic
Shu Jin Chan: University of Chicago, Chicago, Illinois 60637, USA
Donald F. Steiner: University of Chicago, Chicago, Illinois 60637, USA
Guy G. Dodson: York Structural Biology Laboratory, University of York
Andrzej M. Brzozowski: York Structural Biology Laboratory, University of York
Michael A. Weiss: School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
Colin W. Ward: Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
Michael C. Lawrence: Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia

Nature, 2013, vol. 493, issue 7431, 241-245

Abstract: The three-dimensional structure of the insulin–insulin receptor complex has proved elusive, confounded by the complexity of producing the receptor protein; here is the first glimpse of the interaction between insulin and its primary binding site on the insulin receptor, a view based on four crystal structures of insulin bound to truncated insulin receptor complexes.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature11781 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:493:y:2013:i:7431:d:10.1038_nature11781

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature11781

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().