Structure and function of the initially transcribing RNA polymerase II–TFIIB complex

Sarah Sainsbury, Jürgen Niesser and Patrick Cramer ()
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Sarah Sainsbury: Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany
Jürgen Niesser: Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany
Patrick Cramer: Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany

Nature, 2013, vol. 493, issue 7432, 437-440

Abstract: Crystal structures of the Pol II–TFIIB complex in free form and bound by the DNA template and a short RNA product are reported; the latter complex represents an initially transcribing complex, a critical transient state in the pathway from transcription initiation to elongation.

Date: 2013
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DOI: 10.1038/nature11715

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