Exaggerated translation causes synaptic and behavioural aberrations associated with autism

Emanuela Santini, Thu N. Huynh, Andrew F. MacAskill, Adam G. Carter, Philippe Pierre, Davide Ruggero, Hanoch Kaphzan and Eric Klann ()
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Emanuela Santini: Center for Neural Science, New York University
Thu N. Huynh: Center for Neural Science, New York University
Andrew F. MacAskill: Center for Neural Science, New York University
Adam G. Carter: Center for Neural Science, New York University
Philippe Pierre: Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université
Davide Ruggero: School of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94143, USA
Hanoch Kaphzan: Center for Neural Science, New York University
Eric Klann: Center for Neural Science, New York University

Nature, 2013, vol. 493, issue 7432, 411-415

Abstract: Mice overexpressing eIF4E show autism-related behaviours and altered synaptic activity in the hippocampus, prefrontal cortex and striatum, and these phenotypes can be rescued with the cap-dependent translation inhibitor 4EGI-1.

Date: 2013
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DOI: 10.1038/nature11782

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