PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory

Lenora J. Volk, Julia L. Bachman, Richard Johnson, Yilin Yu and Richard L. Huganir ()
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Lenora J. Volk: Howard Hughes Medical Institute, Johns Hopkins University School of Medicine
Julia L. Bachman: Howard Hughes Medical Institute, Johns Hopkins University School of Medicine
Richard Johnson: Howard Hughes Medical Institute, Johns Hopkins University School of Medicine
Yilin Yu: Howard Hughes Medical Institute, Johns Hopkins University School of Medicine
Richard L. Huganir: Howard Hughes Medical Institute, Johns Hopkins University School of Medicine

Nature, 2013, vol. 493, issue 7432, 420-423

Abstract: It was proposed that protein kinase M-ζ (PKM-ζ) is a key factor in long-term potentiation (LTP) and memory maintenance on the basis of the disruption of LTP and memory by inhibitors of PKM-ζ; however, here mice that do not express PKM-ζ are shown to have normal LTP and memory, thus casting doubts on a critical role for PKM-ζ in these processes.

Date: 2013
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DOI: 10.1038/nature11802

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