Prkcz null mice show normal learning and memory

Anna M. Lee, Benjamin R. Kanter, Dan Wang, Jana P. Lim, Mimi E. Zou, Chichen Qiu, Thomas McMahon, Jahan Dadgar, Sarah C. Fischbach-Weiss and Robert O. Messing ()
Additional contact information
Anna M. Lee: Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
Benjamin R. Kanter: Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
Dan Wang: Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
Jana P. Lim: Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
Mimi E. Zou: Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
Chichen Qiu: Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
Thomas McMahon: Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
Jahan Dadgar: Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
Sarah C. Fischbach-Weiss: Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
Robert O. Messing: Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA

Nature, 2013, vol. 493, issue 7432, 416-419

Abstract: Genetically removing PKM-ζ in mice has no effect on memory, and despite absence of this kinase, the original peptide inhibitor of PKM-ζ still disrupts memory in these mutant mice; these data re-open the exploration for key molecules regulating maintenance of long-term plasticity processes.

Date: 2013
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DOI: 10.1038/nature11803

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