Metabolism of inflammation limited by AMPK and pseudo-starvation

Luke A. J. O'Neill () and D. Grahame Hardie
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Luke A. J. O'Neill: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
D. Grahame Hardie: College of Life Sciences, University of Dundee

Nature, 2013, vol. 493, issue 7432, 346-355

Abstract: Abstract Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1β and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.

Date: 2013
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DOI: 10.1038/nature11862

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