Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

Dipesh Chaudhury, Jessica J. Walsh, Allyson K. Friedman, Barbara Juarez, Stacy M. Ku, Ja Wook Koo, Deveroux Ferguson, Hsing-Chen Tsai, Lisa Pomeranz, Daniel J. Christoffel, Alexander R. Nectow, Mats Ekstrand, Ana Domingos, Michelle S. Mazei-Robison, Ezekiell Mouzon, Mary Kay Lobo, Rachael L. Neve, Jeffrey M. Friedman, Scott J. Russo, Karl Deisseroth, Eric J. Nestler and Ming-Hu Han ()
Additional contact information
Dipesh Chaudhury: Friedman Brain Institute, Mount Sinai School of Medicine
Jessica J. Walsh: Friedman Brain Institute, Mount Sinai School of Medicine
Allyson K. Friedman: Friedman Brain Institute, Mount Sinai School of Medicine
Barbara Juarez: Friedman Brain Institute, Mount Sinai School of Medicine
Stacy M. Ku: Friedman Brain Institute, Mount Sinai School of Medicine
Ja Wook Koo: Friedman Brain Institute, Mount Sinai School of Medicine
Deveroux Ferguson: Friedman Brain Institute, Mount Sinai School of Medicine
Hsing-Chen Tsai: Stanford University
Lisa Pomeranz: Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University
Daniel J. Christoffel: Friedman Brain Institute, Mount Sinai School of Medicine
Alexander R. Nectow: Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University
Mats Ekstrand: Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University
Ana Domingos: Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University
Michelle S. Mazei-Robison: Friedman Brain Institute, Mount Sinai School of Medicine
Ezekiell Mouzon: Friedman Brain Institute, Mount Sinai School of Medicine
Mary Kay Lobo: Friedman Brain Institute, Mount Sinai School of Medicine
Rachael L. Neve: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Jeffrey M. Friedman: Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University
Scott J. Russo: Friedman Brain Institute, Mount Sinai School of Medicine
Karl Deisseroth: Stanford University
Eric J. Nestler: Friedman Brain Institute, Mount Sinai School of Medicine
Ming-Hu Han: Friedman Brain Institute, Mount Sinai School of Medicine

Nature, 2013, vol. 493, issue 7433, 532-536

Abstract: Optogenetic induction of phasic, but not tonic, firing in VTA dopamine neurons induces susceptibility to stress in mice undergoing a subthreshold social-defeat paradigm and in previously resilient mice that have been subjected to repeated social-defeat stress, and this effect is projection-pathway specific.

Date: 2013
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DOI: 10.1038/nature11713

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