RNAi triggered by specialized machinery silences developmental genes and retrotransposons

Soichiro Yamanaka, Sameet Mehta, Francisca E. Reyes-Turcu, Fanglei Zhuang, Ryan T. Fuchs, Yikang Rong, Gregory B. Robb and Shiv I. S. Grewal ()
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Soichiro Yamanaka: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Sameet Mehta: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Francisca E. Reyes-Turcu: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Fanglei Zhuang: New England Biolabs
Ryan T. Fuchs: New England Biolabs
Yikang Rong: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Gregory B. Robb: New England Biolabs
Shiv I. S. Grewal: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health

Nature, 2013, vol. 493, issue 7433, 557-560

Abstract: In the fission yeast Schizosaccharomyces pombe RNA interference (RNAi) machinery promotes heterochromatin assembly and silencing of centromeric repeats; here it is shown that RNAi participates in silencing other genomic regions, such as sexual differentiation genes and retrotransposons, and this process is regulated by developmental and environmental signals.

Date: 2013
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DOI: 10.1038/nature11716

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