Dopamine neurons modulate neural encoding and expression of depression-related behaviour

Kay M. Tye (), Julie J. Mirzabekov, Melissa R. Warden, Emily A. Ferenczi, Hsing-Chen Tsai, Joel Finkelstein, Sung-Yon Kim, Avishek Adhikari, Kimberly R. Thompson, Aaron S. Andalman, Lisa A. Gunaydin, Ilana B. Witten and Karl Deisseroth ()
Additional contact information
Kay M. Tye: Picower Institute for Learning and Memory, Brain and Cognitive Sciences, Massachusetts Institute of Technology
Julie J. Mirzabekov: Stanford University
Melissa R. Warden: Stanford University
Emily A. Ferenczi: Stanford University
Hsing-Chen Tsai: Stanford University
Joel Finkelstein: Stanford University
Sung-Yon Kim: Stanford University
Avishek Adhikari: Stanford University
Kimberly R. Thompson: Stanford University
Aaron S. Andalman: Stanford University
Lisa A. Gunaydin: Stanford University
Ilana B. Witten: Stanford University
Karl Deisseroth: Stanford University

Nature, 2013, vol. 493, issue 7433, 537-541

Abstract: Specific manipulation of midbrain dopamine neurons in freely moving rodents shows that their inhibition or excitation immediately modulates depression-like phenotypes that are induced by chronic mild stress, and that their activation alters the neural encoding of depression-related behaviours in the nucleus accumbens.

Date: 2013
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DOI: 10.1038/nature11740

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