TET2 promotes histone O-GlcNAcylation during gene transcription

Qiang Chen, Yibin Chen, Chunjing Bian, Ryoji Fujiki and Xiaochun Yu ()
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Qiang Chen: University of Michigan Medical School, 1150 West Medical Center Drive, 5560A MSRBII, Ann Arbor, Michigan 48109, USA
Yibin Chen: University of Michigan Medical School, 1150 West Medical Center Drive, 5560A MSRBII, Ann Arbor, Michigan 48109, USA
Chunjing Bian: University of Michigan Medical School, 1150 West Medical Center Drive, 5560A MSRBII, Ann Arbor, Michigan 48109, USA
Ryoji Fujiki: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Xiaochun Yu: University of Michigan Medical School, 1150 West Medical Center Drive, 5560A MSRBII, Ann Arbor, Michigan 48109, USA

Nature, 2013, vol. 493, issue 7433, 561-564

Abstract: TET2 is shown to associate with OGT, which catalyses O-GlcNAcylation, and the two enzymes are found together at transcription start sites; TET2 facilitates the activity of OGT in O-GlcNAcylation of histone 2B, and epigenetic modifications to both DNA and histones by TET2 and OGT may be important in gene transcription regulation.

Date: 2013
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DOI: 10.1038/nature11742

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