Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Oliver D. K. Maddocks, Celia R. Berkers, Susan M. Mason, Liang Zheng, Karen Blyth, Eyal Gottlieb and Karen H. Vousden ()
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Oliver D. K. Maddocks: The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
Celia R. Berkers: The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
Susan M. Mason: The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
Liang Zheng: The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
Karen Blyth: The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
Eyal Gottlieb: The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
Karen H. Vousden: The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK

Nature, 2013, vol. 493, issue 7433, 542-546

Abstract: The authors show that p53 helps cancer cells survive serine depletion by coordinating metabolic remodelling; a diet lacking serine slowed tumour growth in mice, with p53-null tumours showing greatest sensitivity to serine starvation.

Date: 2013
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DOI: 10.1038/nature11743

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