NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka (), Markus P. Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng, Ellen Gelpi, Annett Halle, Martin Korte, Eicke Latz () and Douglas T. Golenbock ()
Additional contact information
Michael T. Heneka: Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany
Markus P. Kummer: Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany
Andrea Stutz: Institute of Innate Immunity, University of Bonn
Andrea Delekate: Zoological Institute, Technische Universität Braunschweig
Stephanie Schwartz: Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany
Ana Vieira-Saecker: Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany
Angelika Griep: Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany
Daisy Axt: Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany
Anita Remus: Zoological Institute, Technische Universität Braunschweig
Te-Chen Tzeng: University of Massachusetts Medical School
Ellen Gelpi: Neurological Tissue Bank, University of Barcelona-Hospital Clinic, IDIBAPS, 08036 Barcelona, Spain
Annett Halle: Center for Advanced European Studies and Research-CAESAR
Martin Korte: Zoological Institute, Technische Universität Braunschweig
Eicke Latz: Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
Douglas T. Golenbock: University of Massachusetts Medical School

Nature, 2013, vol. 493, issue 7434, 674-678

Abstract: Alzheimer’s-prone mice deficient in NLRP3 or caspase-1 fail to develop learning deficits and show reduced neuropathology.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (7)

Downloads: (external link)
https://www.nature.com/articles/nature11729 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:493:y:2013:i:7434:d:10.1038_nature11729

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature11729

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().