Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

Alejo Efeyan, Roberto Zoncu, Steven Chang, Iwona Gumper, Harriet Snitkin, Rachel L. Wolfson, Oktay Kirak, David D. Sabatini and David M. Sabatini ()
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Alejo Efeyan: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Roberto Zoncu: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Steven Chang: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Iwona Gumper: New York University School of Medicine
Harriet Snitkin: New York University School of Medicine
Rachel L. Wolfson: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Oktay Kirak: Whitehead Institute for Biomedical Research, Nine Cambridge Center
David D. Sabatini: New York University School of Medicine
David M. Sabatini: Whitehead Institute for Biomedical Research, Nine Cambridge Center

Nature, 2013, vol. 493, issue 7434, 679-683

Abstract: Mice expressing a constitutively active form of RagA are unable to inhibit mTORC1 after birth and to trigger autophagy, and succumb perinatally.

Date: 2013
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DOI: 10.1038/nature11745

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