Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

Peng Jiang, Wenjing Du, Anthony Mancuso, Kathryn E. Wellen and Xiaolu Yang ()
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Peng Jiang: University of Pennsylvania School of Medicine
Wenjing Du: University of Pennsylvania School of Medicine
Anthony Mancuso: University of Pennsylvania School of Medicine
Kathryn E. Wellen: University of Pennsylvania School of Medicine
Xiaolu Yang: University of Pennsylvania School of Medicine

Nature, 2013, vol. 493, issue 7434, 689-693

Abstract: Evidence for a link between cellular senescence and metabolic regulation is provided, through the observation that p53 represses the expression of malic enzymes, thereby regulating NADPH, lipid and glutamine metabolism; in turn, this repression further activates p53, promoting cellular senescence.

Date: 2013
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DOI: 10.1038/nature11776

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