Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence

Yuval Tabach, Allison C. Billi, Gabriel D. Hayes, Martin A. Newman, Or Zuk, Harrison Gabel, Ravi Kamath, Keren Yacoby, Brad Chapman, Susana M. Garcia, Mark Borowsky, John K. Kim and Gary Ruvkun ()
Additional contact information
Yuval Tabach: Massachusetts General Hospital
Allison C. Billi: Life Sciences Institute, University of Michigan
Gabriel D. Hayes: Massachusetts General Hospital
Martin A. Newman: Massachusetts General Hospital
Or Zuk: Broad Institute of MIT and Harvard
Harrison Gabel: Massachusetts General Hospital
Ravi Kamath: Massachusetts General Hospital
Keren Yacoby: Massachusetts General Hospital
Brad Chapman: Massachusetts General Hospital
Susana M. Garcia: Massachusetts General Hospital
Mark Borowsky: Massachusetts General Hospital
John K. Kim: Life Sciences Institute, University of Michigan
Gary Ruvkun: Massachusetts General Hospital

Nature, 2013, vol. 493, issue 7434, 694-698

Abstract: To identify comprehensively factors involved in RNAi and microRNA-mediated gene expression regulation, this study performed a phylogenetic analysis of 86 eukaryotic species; the candidates this approach highlighted were subjected to Bayesian analysis with transcriptional and proteomic interaction data, identifying protein orthologues of already known RNAi silencing factors, as well as other hits involved in splicing, suggesting a connection between the two processes.

Date: 2013
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DOI: 10.1038/nature11779

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