Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

Jan-Wilhelm Kornfeld, Catherina Baitzel, A. Christine Könner, Hayley T. Nicholls, Merly C. Vogt, Karolin Herrmanns, Ludger Scheja, Cécile Haumaitre, Anna M. Wolf, Uwe Knippschild, Jost Seibler, Silvia Cereghini, Joerg Heeren, Markus Stoffel and Jens C. Brüning ()
Additional contact information
Jan-Wilhelm Kornfeld: Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Cologne, Germany
Catherina Baitzel: Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Cologne, Germany
A. Christine Könner: Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Cologne, Germany
Hayley T. Nicholls: Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Cologne, Germany
Merly C. Vogt: Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Cologne, Germany
Karolin Herrmanns: Swiss Federal Institute of Technology (ETH Zurich), Institute of Molecular Health Science, Schafmattstrasse 22, 8093 Zurich, Switzerland
Ludger Scheja: University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Cécile Haumaitre: INSERM U 969, 9 Quai Saint Bernard, 75005 Paris, France
Anna M. Wolf: University Hospital of Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany
Uwe Knippschild: University Hospital of Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany
Jost Seibler: TaconicArtemis GmbH, Neurather Ring 1, 51063 Cologne, Germany
Silvia Cereghini: INSERM U 969, 9 Quai Saint Bernard, 75005 Paris, France
Joerg Heeren: University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Markus Stoffel: Swiss Federal Institute of Technology (ETH Zurich), Institute of Molecular Health Science, Schafmattstrasse 22, 8093 Zurich, Switzerland
Jens C. Brüning: Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Cologne, Germany

Nature, 2013, vol. 494, issue 7435, 111-115

Abstract: The livers of obese mice and humans show increased levels of miR-802 resulting in impaired glucose tolerance and decreased insulin sensitivity through silencing of Hnf1b, revealing a novel pathway with potential relevance for type 2 diabetes.

Date: 2013
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DOI: 10.1038/nature11793

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