Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

Changsung Kim, Johnson Wong, Jianyan Wen, Shirong Wang, Cheng Wang, Sean Spiering, Natalia G. Kan, Sonia Forcales, Pier Lorenzo Puri, Teresa C. Leone, Joseph E. Marine, Hugh Calkins, Daniel P. Kelly, Daniel P. Judge and Huei-Sheng Vincent Chen ()
Additional contact information
Changsung Kim: Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute
Johnson Wong: Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute
Jianyan Wen: Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute
Shirong Wang: Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute
Cheng Wang: Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute
Sean Spiering: Muscle Regeneration and Development Program, Sanford-Burnham Medical Research Institute
Natalia G. Kan: Muscle Regeneration and Development Program, Sanford-Burnham Medical Research Institute
Sonia Forcales: Muscle Regeneration and Development Program, Sanford-Burnham Medical Research Institute
Pier Lorenzo Puri: Muscle Regeneration and Development Program, Sanford-Burnham Medical Research Institute
Teresa C. Leone: Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute
Joseph E. Marine: Johns Hopkins University School of Medicine
Hugh Calkins: Johns Hopkins University School of Medicine
Daniel P. Kelly: Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute
Daniel P. Judge: Johns Hopkins University School of Medicine
Huei-Sheng Vincent Chen: Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute

Nature, 2013, vol. 494, issue 7435, 105-110

Abstract: This study demonstrates that an inheritable adult onset heart disease can be modelled in vitro within months with the help of metabolic maturation induction.

Date: 2013
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DOI: 10.1038/nature11799

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