Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells

Ryoko Araki, Masahiro Uda, Yuko Hoki, Misato Sunayama, Miki Nakamura, Shunsuke Ando, Mayumi Sugiura, Hisashi Ideno, Akemi Shimada, Akira Nifuji and Masumi Abe ()
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Ryoko Araki: Transcriptome Research Group, National Institute of Radiological Sciences
Masahiro Uda: Transcriptome Research Group, National Institute of Radiological Sciences
Yuko Hoki: Transcriptome Research Group, National Institute of Radiological Sciences
Misato Sunayama: Transcriptome Research Group, National Institute of Radiological Sciences
Miki Nakamura: Transcriptome Research Group, National Institute of Radiological Sciences
Shunsuke Ando: Transcriptome Research Group, National Institute of Radiological Sciences
Mayumi Sugiura: Transcriptome Research Group, National Institute of Radiological Sciences
Hisashi Ideno: Transcriptome Research Group, National Institute of Radiological Sciences
Akemi Shimada: School of Dental Medicine, Tsurumi University
Akira Nifuji: Transcriptome Research Group, National Institute of Radiological Sciences
Masumi Abe: Transcriptome Research Group, National Institute of Radiological Sciences

Nature, 2013, vol. 494, issue 7435, 100-104

Abstract: Immune rejection may limit the therapeutic use of induced pluripotent stem cells (iPSCs); here, terminally differentiated mouse iPSCs are shown to generate negligible immune rejection in their host.

Date: 2013
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DOI: 10.1038/nature11807

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