tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans

Marios Chatzigeorgiou, Sangsu Bang, Sun Wook Hwang () and William R. Schafer ()
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Marios Chatzigeorgiou: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Sangsu Bang: Korea University College of Medicine, Seoul 136-705, Korea
Sun Wook Hwang: Korea University College of Medicine, Seoul 136-705, Korea
William R. Schafer: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

Nature, 2013, vol. 494, issue 7435, 95-99

Abstract: The membrane protein TMC-1 is required for salt avoidance behaviour in C. elegans, functions as an ion channel directly activated by NaCl in vitro and is a candidate salt chemosensor; the human homologue of TMC-1 is linked to deafness and may be the cochlear hair-cell mechanotransduction channel.

Date: 2013
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DOI: 10.1038/nature11845

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