A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

Christoph S. N. Klose, Elina A. Kiss, Vera Schwierzeck, Karolina Ebert, Thomas Hoyler, Yannick d’Hargues, Nathalie Göppert, Andrew L. Croxford, Ari Waisman, Yakup Tanriver and Andreas Diefenbach ()
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Christoph S. N. Klose: Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
Elina A. Kiss: Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
Vera Schwierzeck: Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
Karolina Ebert: Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
Thomas Hoyler: Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
Yannick d’Hargues: Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
Nathalie Göppert: Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
Andrew L. Croxford: Institute of Molecular Medicine, University of Mainz, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany
Ari Waisman: Institute of Molecular Medicine, University of Mainz, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany
Yakup Tanriver: Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
Andreas Diefenbach: Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany

Nature, 2013, vol. 494, issue 7436, 261-265

Abstract: The graded expression of the transcription factor T-bet in CCR6−RORγt+ innate lymphoid cells is found to be involved in the control of interferon-γ expression, a cytokine that is required to protect the epithelial barrier against Salmonella infections.

Date: 2013
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DOI: 10.1038/nature11813

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