Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

Meghna Das Thakur, Fernando Salangsang, Allison S. Landman, William R. Sellers, Nancy K. Pryer, Mitchell P. Levesque, Reinhard Dummer, Martin McMahon () and Darrin D. Stuart ()
Additional contact information
Meghna Das Thakur: Novartis Institutes for Biomedical Research
Fernando Salangsang: Novartis Institutes for Biomedical Research
Allison S. Landman: University of California San Francisco
William R. Sellers: Novartis Institutes for Biomedical Research
Nancy K. Pryer: Novartis Institutes for Biomedical Research
Mitchell P. Levesque: University Hospital Zurich, Gloriastrasse 31, 8091 Zürich, Switzerland
Reinhard Dummer: University Hospital Zurich, Gloriastrasse 31, 8091 Zürich, Switzerland
Martin McMahon: University of California San Francisco
Darrin D. Stuart: Novartis Institutes for Biomedical Research

Nature, 2013, vol. 494, issue 7436, 251-255

Abstract: BRAF inhibitors such as vemurafenib have shown promising effects in patients with BRAF-mutant melanomas, but the tumours generally develop resistance; vemurafenib-resistant melanomas are now shown to be drug dependent, and an intermittent dosing schedule can help prevent drug resistance.

Date: 2013
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DOI: 10.1038/nature11814

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