A direct and melanopsin-dependent fetal light response regulates mouse eye development

Sujata Rao, Christina Chun, Jieqing Fan, J. Matthew Kofron, Michael B. Yang, Rashmi S. Hegde, Napoleone Ferrara, David R. Copenhagen () and Richard A. Lang ()
Additional contact information
Sujata Rao: The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center
Christina Chun: University of California, San Francisco, San Francisco, California 94158, USA
Jieqing Fan: The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center
J. Matthew Kofron: Cincinnati Children’s Hospital Medical Center
Michael B. Yang: The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center
Rashmi S. Hegde: Cincinnati Children’s Hospital Medical Center
Napoleone Ferrara: Genentech Inc., 1 DNA Way
David R. Copenhagen: University of California, San Francisco, San Francisco, California 94158, USA
Richard A. Lang: The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center

Nature, 2013, vol. 494, issue 7436, 243-246

Abstract: During retinal vascular development there is simultaneous regression of the hyaloid vasculature and formation of the retinal vasculature; here it is demonstrated that regression of developing vasculature is light dependent and acts via the photoreceptor melanopsin.

Date: 2013
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DOI: 10.1038/nature11823

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