Concurrent activation of striatal direct and indirect pathways during action initiation

Guohong Cui, Sang Beom Jun, Xin Jin, Michael D. Pham, Steven S. Vogel (), David M. Lovinger () and Rui M. Costa ()
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Guohong Cui: Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA
Sang Beom Jun: Ewha Womans University, Seoul 120-750, Korea
Xin Jin: Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA
Michael D. Pham: Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA
Steven S. Vogel: Section on Cellular Biophotonics, Laboratory for Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda 20892-9412, Maryland, USA
David M. Lovinger: Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA
Rui M. Costa: Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA

Nature, 2013, vol. 494, issue 7436, 238-242

Abstract: In mice performing an operant task, increases in neural activity in direct- and indirect-pathway spiny projection neurons (SPNs) are associated with action initiation but not with inactivity, and concurrent activation of SPNs from both pathways in one hemisphere precedes the initiation of contraversive movements.

Date: 2013
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DOI: 10.1038/nature11846

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