Molecular signatures of G-protein-coupled receptors

A. J. Venkatakrishnan (), Xavier Deupi, Guillaume Lebon, Christopher G. Tate, Gebhard F. Schertler and M. Madan Babu ()
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A. J. Venkatakrishnan: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Xavier Deupi: Paul Scherrer Institute, 5232 Villigen PSI, Switzerland
Guillaume Lebon: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Christopher G. Tate: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Gebhard F. Schertler: Paul Scherrer Institute, 5232 Villigen PSI, Switzerland
M. Madan Babu: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

Nature, 2013, vol. 494, issue 7436, 185-194

Abstract: A systematic investigation of high-resolution G-protein-coupled receptor (GPCR) structures uncovers a conserved inter-helical network of non-covalent contacts that defines the GPCR fold, and provides insights into the molecular determinants of different GPCR conformations.

Date: 2013
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DOI: 10.1038/nature11896

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