T-helper-1-cell cytokines drive cancer into senescence

Heidi Braumüller, Thomas Wieder, Ellen Brenner, Sonja Aßmann, Matthias Hahn, Mohammed Alkhaled, Karin Schilbach, Frank Essmann, Manfred Kneilling, Christoph Griessinger, Felicia Ranta, Susanne Ullrich, Ralph Mocikat, Kilian Braungart, Tarun Mehra, Birgit Fehrenbacher, Julia Berdel, Heike Niessner, Friedegund Meier, Maries van den Broek, Hans-Ulrich Häring, Rupert Handgretinger, Leticia Quintanilla-Martinez, Falko Fend, Marina Pesic, Jürgen Bauer, Lars Zender, Martin Schaller, Klaus Schulze-Osthoff and Martin Röcken ()
Additional contact information
Heidi Braumüller: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Thomas Wieder: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Ellen Brenner: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Sonja Aßmann: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Matthias Hahn: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Mohammed Alkhaled: Oncology/Hematology, Eberhard Karls University, Hoppe-Seyler-Strasse 1, 72076 Tübingen, Germany
Karin Schilbach: Oncology/Hematology, Eberhard Karls University, Hoppe-Seyler-Strasse 1, 72076 Tübingen, Germany
Frank Essmann: Interfaculty Institute for Biochemistry, Eberhard Karls University, Hoppe-Seyler-Strasse 4, 72076 Tübingen, Germany
Manfred Kneilling: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Christoph Griessinger: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Felicia Ranta: Endocrinology, Diabetology and Clinical Chemistry, Eberhard Karls University, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany
Susanne Ullrich: Endocrinology, Diabetology and Clinical Chemistry, Eberhard Karls University, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany
Ralph Mocikat: Institut für Molekulare Immunologie, Helmholtz-Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Marchionini Strasse 25, 81377 München, Germany
Kilian Braungart: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Tarun Mehra: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Birgit Fehrenbacher: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Julia Berdel: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Heike Niessner: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Friedegund Meier: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Maries van den Broek: Clinic of Oncology, University Hospital Zurich, Raemistrasse 100, 8091 Zürich, Switzerland
Hans-Ulrich Häring: Endocrinology, Diabetology and Clinical Chemistry, Eberhard Karls University, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany
Rupert Handgretinger: Oncology/Hematology, Eberhard Karls University, Hoppe-Seyler-Strasse 1, 72076 Tübingen, Germany
Leticia Quintanilla-Martinez: Eberhard Karls University, Liebermeister Strasse 8, 72076 Tübingen, Germany
Falko Fend: Comprehensive Cancer Center Tübingen, German Cancer Consortium (DKTK), Herrenberger Strasse 23, D-72070 Tübingen, Germany
Marina Pesic: Eberhard Karls University, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany
Jürgen Bauer: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Lars Zender: Eberhard Karls University, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany
Martin Schaller: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
Klaus Schulze-Osthoff: Interfaculty Institute for Biochemistry, Eberhard Karls University, Hoppe-Seyler-Strasse 4, 72076 Tübingen, Germany
Martin Röcken: Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany

Nature, 2013, vol. 494, issue 7437, 361-365

Abstract: T-helper-1-cell cytokines tumour necrosis factor and interferon-γ are shown to drive tumour cells into senescence in a mouse model of β-cell carcinoma and human carcinoma cells.

Date: 2013
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DOI: 10.1038/nature11824

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