Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

Ruisheng Song, Wei Peng, Yan Zhang, Fengxiang Lv, Hong-Kun Wu, Jiaojiao Guo, Yongxing Cao, Yanbin Pi, Xin Zhang, Li Jin, Mao Zhang, Peng Jiang, Fenghua Liu, Shaoshuai Meng, Xiuqin Zhang, Ping Jiang, Chun-Mei Cao () and Rui-Ping Xiao ()
Additional contact information
Ruisheng Song: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Wei Peng: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Yan Zhang: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Fengxiang Lv: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Hong-Kun Wu: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Jiaojiao Guo: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Yongxing Cao: Institute of Sports Medicine, Peking University Third Hospital
Yanbin Pi: Institute of Sports Medicine, Peking University Third Hospital
Xin Zhang: Institute of Sports Medicine, Peking University Third Hospital
Li Jin: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Mao Zhang: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Peng Jiang: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Fenghua Liu: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Shaoshuai Meng: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Xiuqin Zhang: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Ping Jiang: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Chun-Mei Cao: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Rui-Ping Xiao: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University

Nature, 2013, vol. 494, issue 7437, 375-379

Abstract: MG53 acts as an E3 ligase that targets the insulin receptor and IRS1 for ubiquitin-dependent degradation; when MG53 is upregulated, metabolic syndrome ensues.

Date: 2013
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DOI: 10.1038/nature11834

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