APOBEC3B is an enzymatic source of mutation in breast cancer

Michael B. Burns, Lela Lackey, Michael A. Carpenter, Anurag Rathore, Allison M. Land, Brandon Leonard, Eric W. Refsland, Delshanee Kotandeniya, Natalia Tretyakova, Jason B. Nikas, Douglas Yee, Nuri A. Temiz, Duncan E. Donohue, Rebecca M. McDougle, William L. Brown, Emily K. Law and Reuben S. Harris ()
Additional contact information
Michael B. Burns: Biochemistry, University of Minnesota
Lela Lackey: Biochemistry, University of Minnesota
Michael A. Carpenter: Biochemistry, University of Minnesota
Anurag Rathore: Biochemistry, University of Minnesota
Allison M. Land: Biochemistry, University of Minnesota
Brandon Leonard: Masonic Cancer Center, University of Minnesota
Eric W. Refsland: Biochemistry, University of Minnesota
Delshanee Kotandeniya: Masonic Cancer Center, University of Minnesota
Natalia Tretyakova: Masonic Cancer Center, University of Minnesota
Jason B. Nikas: Masonic Cancer Center, University of Minnesota
Douglas Yee: Masonic Cancer Center, University of Minnesota
Nuri A. Temiz: In Silico Research Centers of Excellence, Advanced Biomedical Computing Center, Information Systems Program, SAIC-Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
Duncan E. Donohue: In Silico Research Centers of Excellence, Advanced Biomedical Computing Center, Information Systems Program, SAIC-Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
Rebecca M. McDougle: Biochemistry, University of Minnesota
William L. Brown: Biochemistry, University of Minnesota
Emily K. Law: Biochemistry, University of Minnesota
Reuben S. Harris: Biochemistry, University of Minnesota

Nature, 2013, vol. 494, issue 7437, 366-370

Abstract: The DNA cytosine deaminase APOBEC3B is shown to be overexpressed and highly active in most breast cancers; deamination by APOBEC3B could serve as an endogenous, continual source of DNA damage leading to mutations, including C-to-T transitions and other aberrations seen in many breast tumours.

Date: 2013
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DOI: 10.1038/nature11881

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