A two-step mechanism for TRF2-mediated chromosome-end protection

Keiji Okamoto, Cristina Bartocci, Iliana Ouzounov, Jolene K. Diedrich, John R. Yates and Eros Lazzerini Denchi ()
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Keiji Okamoto: Laboratory of Chromosome Biology and Genomic Stability, The Scripps Research Institute
Cristina Bartocci: Laboratory of Chromosome Biology and Genomic Stability, The Scripps Research Institute
Iliana Ouzounov: Laboratory of Chromosome Biology and Genomic Stability, The Scripps Research Institute
Jolene K. Diedrich: The Scripps Research Institute
John R. Yates: The Scripps Research Institute
Eros Lazzerini Denchi: Laboratory of Chromosome Biology and Genomic Stability, The Scripps Research Institute

Nature, 2013, vol. 494, issue 7438, 502-505

Abstract: The telomere-biding protein TRF2 is shown to protect telomeres from activating the DNA-damage response through two mechanisms: preventing the activation ATM kinase through its dimerization domain, in addition to independently suppressing signalling events occurring downstream of ATM.

Date: 2013
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DOI: 10.1038/nature11873

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