High salt recruits aversive taste pathways

Yuki Oka, Matthew Butnaru, Lars von Buchholtz, Nicholas J. P. Ryba () and Charles S. Zuker ()
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Yuki Oka: Columbia College of Physicians and Surgeons, Columbia University
Matthew Butnaru: Columbia College of Physicians and Surgeons, Columbia University
Lars von Buchholtz: National Institute of Dental and Craniofacial Research, National Institutes of Health
Nicholas J. P. Ryba: National Institute of Dental and Craniofacial Research, National Institutes of Health
Charles S. Zuker: Columbia College of Physicians and Surgeons, Columbia University

Nature, 2013, vol. 494, issue 7438, 472-475

Abstract: High concentrations of salt activate sour- and bitter-taste-sensing cells in the tongues of mice, and genetic silencing of these pathways abolishes behavioural aversion to concentrated salt; this ‘co-opting’ of the two primary aversive taste pathways (sour and bitter) may have evolved so that high salt levels reliably trigger behavioural rejection.

Date: 2013
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DOI: 10.1038/nature11905

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