A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity

Kimberley D. Seed, David W. Lazinski, Stephen B. Calderwood and Andrew Camilli ()
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Kimberley D. Seed: Tufts University School of Medicine
David W. Lazinski: Tufts University School of Medicine
Stephen B. Calderwood: Massachusetts General Hospital
Andrew Camilli: Tufts University School of Medicine

Nature, 2013, vol. 494, issue 7438, 489-491

Abstract: CRISPR/Cas systems are bacterial adaptive immune systems that provide sequence-specific protection from invading nucleic acids, including from bacteriophages; in a notable reverse a vibriophage-encoded CRISPR/Cas system, used to disable a bacteriophage inhibitory chromosomal island in Vibrio cholerae, is identified.

Date: 2013
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DOI: 10.1038/nature11927

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