Non-optimal codon usage affects expression, structure and function of clock protein FRQ

Mian Zhou, Jinhu Guo, Joonseok Cha, Michael Chae, She Chen, Jose M. Barral, Matthew S. Sachs and Yi Liu ()
Additional contact information
Mian Zhou: The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Jinhu Guo: The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Joonseok Cha: The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Michael Chae: The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
She Chen: National Institute of Biological Sciences, 7 Life Science Park Road, Changping District, Beijing 102206, China
Jose M. Barral: The University of Texas Medical Branch
Matthew S. Sachs: Texas A&M University
Yi Liu: The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA

Nature, 2013, vol. 495, issue 7439, 111-115

Abstract: The frq gene, essential for circadian clock function, is shown to differ from most other genes in Neurospora by exhibiting non-optimal codon usage; by contrast, optimization of codon usage is unexpectedly found to affect the structure and function of the coded protein, subsequently impairing circadian feedback loops.

Date: 2013
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DOI: 10.1038/nature11833

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