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‘See-saw’ expression of microRNA-198 and FSTL1 from a single transcript in wound healing

Gopinath M. Sundaram, John E. A. Common, Felicia E. Gopal, Satyanarayana Srikanta, Krishnaswamy Lakshman, Declan P. Lunny, Thiam C. Lim, Vivek Tanavde, E. Birgitte Lane and Prabha Sampath ()
Additional contact information
Gopinath M. Sundaram: Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore
John E. A. Common: Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore
Felicia E. Gopal: Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore
Satyanarayana Srikanta: Jnana Sanjeevini Diabetes Center, Bangalore 560078, India
Krishnaswamy Lakshman: Jnana Sanjeevini Diabetes Center, Bangalore 560078, India
Declan P. Lunny: Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore
Thiam C. Lim: Reconstructive & Aesthetic Surgery, National University Health System, 119074, Singapore
Vivek Tanavde: Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore
E. Birgitte Lane: Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore
Prabha Sampath: Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore

Nature, 2013, vol. 495, issue 7439, 103-106

Abstract: A post-transcriptional switch that controls spatiotemporal and mutually exclusive expression of two alternative gene products from a single transcript is reported; these gene products—miR-198 and FSTL1—are found to have opposing functions on keratinocyte migration and wound healing.

Date: 2013
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DOI: 10.1038/nature11890

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