MicroRNA-34a regulates cardiac ageing and function

Reinier A. Boon, Kazuma Iekushi, Stefanie Lechner, Timon Seeger, Ariane Fischer, Susanne Heydt, David Kaluza, Karine Tréguer, Guillaume Carmona, Angelika Bonauer, Anton J. G. Horrevoets, Nathalie Didier, Zenawit Girmatsion, Peter Biliczki, Joachim R. Ehrlich, Hugo A. Katus, Oliver J. Müller, Michael Potente, Andreas M. Zeiher, Heiko Hermeking and Stefanie Dimmeler ()
Additional contact information
Reinier A. Boon: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
Kazuma Iekushi: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
Stefanie Lechner: Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, 80337 Munich, Germany
Timon Seeger: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
Ariane Fischer: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
Susanne Heydt: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
David Kaluza: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
Karine Tréguer: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
Guillaume Carmona: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
Angelika Bonauer: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
Anton J. G. Horrevoets: VU University Medical Center, 1081BT Amsterdam, the Netherlands
Nathalie Didier: Myology Group, UMR S787 INSERM, Université Pierre et Marie Curie Paris VI, Institut de Myologie, Pitie-Salpétrière, Paris Cedex, France
Zenawit Girmatsion: Internal Medicine III, Goethe University, 60590 Frankfurt, Germany
Peter Biliczki: Internal Medicine III, Goethe University, 60590 Frankfurt, Germany
Joachim R. Ehrlich: Internal Medicine III, Goethe University, 60590 Frankfurt, Germany
Hugo A. Katus: Internal Medicine III, Heidelberg Universiy Hospital, 69120 Heidelberg, Germany
Oliver J. Müller: Internal Medicine III, Heidelberg Universiy Hospital, 69120 Heidelberg, Germany
Michael Potente: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
Andreas M. Zeiher: Internal Medicine III, Goethe University, 60590 Frankfurt, Germany
Heiko Hermeking: Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, 80337 Munich, Germany
Stefanie Dimmeler: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany

Nature, 2013, vol. 495, issue 7439, 107-110

Abstract: A role is demonstrated for miR-34a, a microRNA that is upregulated in the ageing heart; miR-34a downregulates PNUTS, a protein that protects cardiomyocytes and telomeres, silencing of miR-34a is therefore a promising therapeutic target.

Date: 2013
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DOI: 10.1038/nature11919

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