Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state

Chikashi Toyoshima (), Shiho Iwasawa, Haruo Ogawa, Ayami Hirata, Junko Tsueda and Giuseppe Inesi
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Chikashi Toyoshima: Institute of Molecular and Cellular Biosciences, The University of Tokyo
Shiho Iwasawa: Institute of Molecular and Cellular Biosciences, The University of Tokyo
Haruo Ogawa: Institute of Molecular and Cellular Biosciences, The University of Tokyo
Ayami Hirata: Institute of Molecular and Cellular Biosciences, The University of Tokyo
Junko Tsueda: Institute of Molecular and Cellular Biosciences, The University of Tokyo
Giuseppe Inesi: California Pacific Medical Center Research Institute

Nature, 2013, vol. 495, issue 7440, 260-264

Abstract: The X-ray crystal structures of SERCA1a, a Ca2+-ATPase from the sarcoplasmic reticulum, in the presence and absence of sarcolipin are reported; the structures indicate that sarcolipin stabilizes SERCA1a in an ‘open’ state that has not been well characterised previously, in which SERCA1a has not yet accepted calcium into its two high-affinity binding sites.

Date: 2013
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DOI: 10.1038/nature11899

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