CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

Akiyuki Taruno, Valérie Vingtdeux, Makoto Ohmoto, Zhongming Ma, Gennady Dvoryanchikov, Ang Li, Leslie Adrien, Haitian Zhao, Sze Leung, Maria Abernethy, Jeremy Koppel, Peter Davies, Mortimer M. Civan, Nirupa Chaudhari, Ichiro Matsumoto, Göran Hellekant, Michael G. Tordoff, Philippe Marambaud () and J. Kevin Foskett ()
Additional contact information
Akiyuki Taruno: University of Pennsylvania
Valérie Vingtdeux: Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research
Makoto Ohmoto: Monell Chemical Senses Center
Zhongming Ma: University of Pennsylvania
Gennady Dvoryanchikov: Miller School of Medicine, University of Miami
Ang Li: University of Pennsylvania
Leslie Adrien: Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research
Haitian Zhao: Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research
Sze Leung: Medical School, University of Minnesota Duluth
Maria Abernethy: Medical School, University of Minnesota Duluth
Jeremy Koppel: Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research
Peter Davies: Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research
Mortimer M. Civan: University of Pennsylvania
Nirupa Chaudhari: Miller School of Medicine, University of Miami
Ichiro Matsumoto: Monell Chemical Senses Center
Göran Hellekant: Medical School, University of Minnesota Duluth
Michael G. Tordoff: Monell Chemical Senses Center
Philippe Marambaud: Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research
J. Kevin Foskett: University of Pennsylvania

Nature, 2013, vol. 495, issue 7440, 223-226

Abstract: The voltage-gated ion channel CALHM1 is vital to taste-stimuli-evoked ATP release from sweet-, bitter- and umami-sensing taste bud cells in mice, but does not seem relevant to the recognition of sour and salty tastes.

Date: 2013
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DOI: 10.1038/nature11906

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