PRC1 coordinates timing of sexual differentiation of female primordial germ cells

Shihori Yokobayashi, Ching-Yeu Liang, Hubertus Kohler, Peter Nestorov, Zichuan Liu, Miguel Vidal, Maarten van Lohuizen, Tim C. Roloff and Antoine H. F. M. Peters ()
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Shihori Yokobayashi: Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Ching-Yeu Liang: Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Hubertus Kohler: Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Peter Nestorov: Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Zichuan Liu: Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Miguel Vidal: Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), 28040 Madrid, Spain
Maarten van Lohuizen: the Netherlands Cancer Institute (NKI), 1066 CX Amsterdam, the Netherlands
Tim C. Roloff: Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Antoine H. F. M. Peters: Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland

Nature, 2013, vol. 495, issue 7440, 236-240

Abstract: The Polycomb repressive complex 1 (PRC1) is found to have important gene-dosage-dependent and sex-specific roles in primordial germ cell (PGC) development, including the maintenance of high levels of Oct4 and Nanog and ensuring the proper timing of meiosis through the suppression of retinoic acid signalling in female PGCs.

Date: 2013
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DOI: 10.1038/nature11918

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