CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

Adam Greenbaum, Yen-Michael S. Hsu, Ryan B. Day, Laura G. Schuettpelz, Matthew J. Christopher, Joshua N. Borgerding, Takashi Nagasawa and Daniel C. Link ()
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Adam Greenbaum: Washington University School of Medicine
Yen-Michael S. Hsu: Washington University School of Medicine
Ryan B. Day: Washington University School of Medicine
Laura G. Schuettpelz: Washington University School of Medicine
Matthew J. Christopher: Washington University School of Medicine
Joshua N. Borgerding: Washington University School of Medicine
Takashi Nagasawa: Institute for Frontier Medical Sciences, Kyoto University
Daniel C. Link: Washington University School of Medicine

Nature, 2013, vol. 495, issue 7440, 227-230

Abstract: Targeted deletion of the chemokine Cxcl12 in different bone marrow stromal cell populations shows that distinct niches exist in the bone marrow for haematopoietic stem cells and lineage-committed progenitors.

Date: 2013
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DOI: 10.1038/nature11926

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