USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

Ji Li, Vincenzo D’Angiolella, E. Scott Seeley, Sehyun Kim, Tetsuo Kobayashi, Wenxiang Fu, Eric I. Campos, Michele Pagano and Brian David Dynlacht ()
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Ji Li: Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA
Vincenzo D’Angiolella: Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA
E. Scott Seeley: University of California San Francisco
Sehyun Kim: Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA
Tetsuo Kobayashi: Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA
Wenxiang Fu: Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA
Eric I. Campos: Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA
Michele Pagano: Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA
Brian David Dynlacht: Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA

Nature, 2013, vol. 495, issue 7440, 255-259

Abstract: Maintenance of normal levels of CP110 is essential to prevent over-duplication of centrosomes and genome instability; here, a deubiquitinating enzyme, USP33, is shown to stabilize CP110.

Date: 2013
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DOI: 10.1038/nature11941

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